Nse in naturally occurring canine spinal cord injury. J. Neuropathol. Exp. Neurol. 70, 703?14. Levine, J.M., Ruaux, C.G., Bergman, R.L., Coates, J.R., Steiner, J.M. and Williams, D.A. (2006). Matrix metalloproteinase-9 activity inside the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease. Am. J. Vet. Res. 67, 283?287. Boekhoff, T.M., Ensinger, E.M., Carlson, R., Bock, P., Baumgartner, W., Rohn, K., Tipold, A. and Stein, V.M. (2012). Microglial contribution to secondary injury evaluated in a significant animal model of human spinal cord trauma. J. Neurotrauma 29, 1000?011. Levine, G.J., Levine, J.M., Witsberger, T.H., Kerwin, S.C., Russell, K.E., Suchodolski, J., Steiner, J. and Fosgate, G.T. (2010). Cerebrospinal fluid myelin simple protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation. J. Vet. Intern. Med. 24, 890?96. Kwon, B.K., Stammers, A.M., Belanger, L.M., Bernardo, A., Chan, D., Bishop, C.M., Slobogean, G.P., Zhang, H., Umedaly, H., Giffin, M., Street, J., Boyd, M.C., Paquette, S.J., Fisher, C.G. and Dvorak, M.6-Bromo-5-chloroimidazo[1,2-a]pyridine custom synthesis F. (2010). Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J. Neurotrauma 27, 669?82. Kwon, B.K., Casha, S., Hurlbert, R.J. and Yong, V.W. (2011). Inflammatory and structural biomarkers in acute traumatic spinal cord injury. Clin. Chem. Lab. Med. 49, 425?33. Brisby, H., Olmarker, K., Larsson, K., Nutu, M. and Rydevik, B. (2002). Proinflammatory cytokines in cerebrospinal fluid and serum in sufferers with disc herniation and sciatica. Eur. Spine J. 11, 62?66. Tsai, M.C., Wei, C.P., Lee, D.Y., Tseng, Y.T., Tsai, M.D., Shih, Y.L., Lee, Y.158326-85-3 Order H.PMID:33745353 , Chang, S.F. and Leu, S.J. (2008). Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury. Surg. Neurol. 70 Suppl. 1, S1:19?four; discussion, S11:24. Levine, G.J., Levine, J.M., Budke, C.M., Kerwin, S.C., Au, J., Vinayak, A., Hettlich, B.F. and Slater, M.R. (2009). Description and repeatability of a newly created spinal cord injury scale for dogs. Prev. Vet. Med. 89, 121?27. Rosner, B. (2010). Fundamentals of Biostatistics, 7th ed. Cengage Mastering: Boston, MA. Pregibon, D. (1984). Critique: P. McCullagh, JA Nelder, Generalized Linear Models. Ann. Stat. 12, 1589?596. Stammers, A.T., Liu, J. and Kwon, B.K. (2012). Expression of inflammatory cytokines following acute spinal cord injury in a rodent model. J. Neurosci. Res. 90, 782?90. Smith, P.M. and Jeffery, N.D. (2006). Histological and ultrastructural evaluation of white matter harm following naturally-occurring spinal cord injury. Brain Pathol. 16, 99?09. Griffiths, I.R. (1972). Some elements with the pathology and pathogenesis on the myelopathy brought on by disc protrusions in dogs. J. Neurol. Neurosurg. Psychiatry 35, 403?13.five.six.7.8.9.10.11.12.13.14. 15.16.
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival below tumor-like stressRegina M. Young,1,two Daniel Ackerman,1 Zachary L. Quinn,1,three Anthony Mancuso,four Michaela Gruber,1,five Liping Liu,1,3,6 Dionysios N. Giannoukos,1,3 Ekaterina Bobrovnikova-Marjon,1,7 J. Alan Diehl,1,two Brian Keith,1,two and M. Celeste Simon1,three,1 Abramson Loved ones Cancer Study Institute, 2Department of Cancer Biology, 3Howard Hughes Medical Institute, 4Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USASolid tumors exhibit heterogeneous microenvironments, often ch.
