Product Name :
PIGR Mouse Monoclonal Antibody [6E5A9]
Predicted band size :
Observed band size :
Synonyms:
Hepatocellular carcinoma associated protein TB6 antibody Hepatocellular carcinoma-associated protein TB6 antibody MGC125361 antibody MGC125362 antibody Phosphatidylinositol glycan class R antibody PIGR antibody PIGR_HUMAN antibody Poly Ig receptor antibody Poly-Ig receptor antibody 展开
Function :
Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A , and immune complexes. pIgRs are mainly located on the epithelial lining of mucosal surfaces of the gastrointestinal tract. The composition of the receptor is complex, including 6 immunoglobulin-like domains, a transmembrane region, and an intracellular domain. pIgR expression is under the strong regulation of cytokines, hormones, and pathogenic stimuli. Polymeric immunoglobulin receptor is responsible for transcytosis of soluble dimeric IgAs and immune complexes from the basolateral to the apical mucosal epithelial cell surface. pIgR has a strong specificity to polymeric immunoglobulins and is not responsive to monomeric immunoglobulin. The ligand’s J-chain is responsible for the binding of pIgR to its ligand.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Purified recombinant fragment of human PIGR (AA: extra 19-170) expressed in E. Coli.
Species reactivity:
Human
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
6E5A9
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
4℃; -20℃ for long term storage.tert-Butyl azetidin-3-ylcarbamate structure
Storage buffer solution:
Purified antibody in PBS with 0.5-Bromo-2-(tert-butyl)pyridine uses 05% sodium azide.PMID:33627375
Subtype:
IgG1
Purification method :
Protein G affinity purified.
ELTSA :
Molecular weight :
83.3kDa
Positive control :
ovarian cancer rectum cancer